2025 MLB All-Star Game odds, line, start time, picks, best bets for Tuesday, July 15, matchup from proven expert

The 2025 MLB All-Star Game features the American League aiming for its second consecutive win and 11th victory in the last 12 meetings against the National League. The AL won the 2024 game 5-3, following the NL ending a nine-game losing streak in 2023. Historically, the AL holds a narrow 48-44-2 advantage in the all-time series and has outscored the NL 388-380 across 94 games.

The game is scheduled for Tuesday at 8 p.m. ET at Truist Park in Atlanta. Betting odds from DraftKings Sportsbook list the National League as a -112 favorite on the money line, requiring a $112 wager to win $100. The over/under for total runs scored is set at 7. The AL boasts a dominant 22-4-1 record in the All-Star Game since 1997.

SportsLine expert Matthew Severance, who holds a 182-110-1 record over his last 293 MLB money line picks (returning over $1,000 for $100 players), is recommending a pick for the game. He is leaning towards betting the Under on the run total and has identified a critical x-factor making one side a strong value pick. His analysis suggests which team to back for the 2025 MLB All-Star Game.