Los Angeles Rams vs San Francisco 49ers Prediction, 11/9/2025 NFL Picks, Best Bets & Odds Week 10

The upcoming NFL game features the Los Angeles Rams (6-2) versus the San Francisco 49ers (6-3) at Levi's Stadium in Santa Clara, CA, on Sunday, November 9, 2025, with broadcast on FOX. The Rams are favored by 4 points, and the over/under total is set at 49.5 points.

In their recent performance, the Los Angeles Rams defeated the New Orleans Saints 34-10, with quarterback Matthew Stafford completing 24 of 32 passes for 281 yards, 4 touchdowns, and a QB rating of 140.8, while avoiding interceptions. Key contributors included Puka Nacua, who had 95 yards on 7 catches, averaging 13.6 yards per reception, and Kyren Williams, who rushed for 114 yards on 25 carries, averaging 4.6 yards per carry. Overall, the Rams executed 75 plays for 438 yards, with 171 rushing yards on 43 attempts and allowed 167 passing yards on 15 completions by the Saints.

Offensively, the Rams average 26.1 points per game and 111.9 rushing yards per game, ranking 18th in the league. They have accumulated 2,959 total yards, achieved 106 first downs, and scored 21 passing touchdowns and 5 rushing touchdowns, but have committed 7 turnovers (2 interceptions and 5 fumbles lost). They also have 41 penalties for 346 yards this season.

Defensively, the Rams rank 2nd in the NFL, allowing only 15.9 points per game. They give up an average of 99.8 rushing yards per game and 3.9 yards per carry, with a total of 798 rushing yards surrendered over 8 games. Against the pass, they have allowed 1,625 yards, ranking 10th, with 203.1 passing yards per game and a 62.3% completion rate. Overall, they yield 302.9 total yards per game (10th in the league) and have conceded 9 passing touchdowns and 2 rushing touchdowns.